High Throughput HPLC Analysis of Barbiturates
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چکیده
In this study, an established HPLC method for USP Phenobarbital was sequentially and quickly improved to a high throughput method using Rapid Resolution (RR) and Rapid Resolution High Throughput (RRHT) techniques. New RRHT column technology is an especially powerful tool for improving lab productivity by reducing HPLC analysis time dramatically. Starting with a proven rugged method, conversion to a high throughput method can be achieved simply by replacing the original analytical-sized column with either a RR or RRHT column. The reasons for this direct conversion include the similar selectivity of smaller 1.8and 3.5-μm particles compared to larger 5-μm particles, and an engineered particle size distribution that reduces unacceptably high system pressures that may be experienced with other sub-two micron packings. High Throughput HPLC Analysis of Barbiturates Application Note
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